Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease Running head: TSLP in coeliac disease
نویسندگان
چکیده
From: First Department of Internal Medicine and Department of Molecular Medicine, St Matteo Hospital, University of Pavia, Pavia, Italy; Centre for Immunobiology, Barts and the London School of Medicine and Dentistry, London, UK; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Faculty of Medicine, University of Southampton, Southampton, UK; Department of Gastroenterology, Norwich University Hospital, Norwich, UK; Academic Department of
منابع مشابه
Recent advances in gastrointestinal immunology.
Biancheri P et al. Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut 2015;0:1-11 The expression of epithelial-derived thymic stromal lymphopoietin (TSLP), a key cytokine modulator of gut immune tolerance, may be dysregulated in coeliac disease (CD). This study investigated TSLP expression along the clinical spectrum of CD and evaluated...
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OBJECTIVE The short isoform of thymic stromal lymphopoietin (TSLP), a cytokine constitutively expressed by epithelial cells, is crucial in preserving immune tolerance in the gut. TSLP deficiency has been implicated in sustaining intestinal damage in Crohn's disease. We explored mucosal TSLP expression and function in refractory and uncomplicated coeliac disease (CD), a T-cell-mediated enteropat...
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PURPOSE Nasal polyposis is a chronic inflammatory disease of the upper airways often associated with asthma and characterized by markedly increased numbers of eosinophils, Th2 type lymphocytes, fibroblasts, goblet cells and mast cells. Previous studies have shown elevated levels of thymic stromal lymphopoietin (TSLP) in atopic diseases like asthma, atopic dermatitis and mainly in animal models ...
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BACKGROUND Coeliac sprue is a chronic disease, in which there is a characteristic mucosal lesion of the small intestine and impaired nutrient absorption, which improves upon the withdrawal of wheat gliadins and related grain proteins from the diet. Biopsy specimens demonstrate diffuse enteritis with pronounced atrophy or total loss of villi. There is also a long term risk of malignant disease. ...
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Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammati...
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